TMEM272

Across TCGA patient cohorts, TMEM272 mutation is significantly associated with the RNA expression of many other genes, with 409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM272-associated genes across cancer lineages are RNY1P1, FBXO7, and PACSIN2. Each is linked with TMEM272 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM272-to-partner and partner-to-TMEM272 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY1P1 grouped by TMEM272-low versus TMEM272-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM272→partner) and Y-score (partner→TMEM272) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNY1P1 →	+0.214	+3.461	<.001	.003	3	2
UCEC	FBXO7 →	+0.507	+3.721	.001	<.001	3	1
UCEC	PACSIN2 →	+0.621	+3.191	<.001	.009	3	1
UCEC	PHF5A →	+0.545	+3.700	.002	.001	3	1
UCEC	PIGH →	+0.578	+3.492	.001	.002	3	1
UCEC	KIAA0586 →	+0.409	+3.234	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 409 associations by consensus.

RNY1P1 by TMEM272 expression — UCEC

Explore this box plot interactively →