TMEM272

Across TCGA pan-cancer cohorts, TMEM272 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TMEM272 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM272 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM272 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, UCEC, and LUSC are the cancer types where TMEM272 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.540	0.250	<.001	130	view →
UCEC	DFS	Tertile	All	0.852	0.927	<.001	72	view →
LUSC	DFS	Quartile	III,IV	0.510	0.908	<.001	52	view →
UCS	DFS	Median	III,IV	0.578	0.264	.006	46	view →
PAAD	OS	Quartile	All	0.540	0.309	.017	37	view →
COAD	DFS	Tertile	All	0.597	0.767	.003	28	view →
READ	OS	Median	II,III,IV	0.986	0.843	.001	22	view →
ACC	DFS	Quartile	II,III,IV	0.300	0.682	.012	19	view →
CHOL	DFS	Quartile	II,III,IV	0.480	0.149	.007	18	view →
PRAD	OS	Tertile	All	0.722	1.000	<.001	18	view →
KIRP	DFS	Tertile	All	0.515	0.807	.002	13	view →
SKCM	OS	Quartile	III,IV	0.568	0.908	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TMEM272–HNSC (DFS)

Open the HNSC breakdown →