TMEM272

Across TCGA patient cohorts, TMEM272 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM272-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and JNK2. Each is linked with TMEM272 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM272-to-partner and partner-to-TMEM272 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TMEM272-low versus TMEM272-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM272→partner) and Y-score (partner→TMEM272) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.243	-3.169	<.001	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.154	-2.999	.018	.035	3	1
UCEC	JNK2 →	+0.404	+3.321	<.001	.010	3	1
UCEC	Ku80 →	+0.291	+2.183	.018	.035	3	1
UCEC	p62 Lck ligand →	+0.349	+2.817	.040	.036	3	1
UCEC	P-Cadherin →	-0.174	-2.990	.021	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

A-Raf_pS299 by TMEM272 expression — UCEC

Explore this box plot interactively →