TMEM272

Across TCGA cell cohorts, TMEM272 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,348 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMEM272-associated GO terms across cancer lineages are Copper ion export, Protein activation cascade, and Regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with TMEM272 in more than 9 cancer types. Because this analysis shows association rather than direction, both TMEM272-to-partner and partner-to-TMEM272 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Copper ion export grouped by TMEM272-low versus TMEM272-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM272→partner) and Y-score (partner→TMEM272) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Copper ion export →	-0.175	-0.065	<.001	.001	3	10
SKIN	Protein activation cascade →	-0.156	-0.653	.005	<.001	3	9
BLOOD_Lymphoma	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.065	+0.076	.002	.004	3	8
LIVER	Regulation of transcription by RNA polymerase I →	+0.084	+0.373	.006	.009	3	8
SOFT_TISSUE	Ribosomal protein import into nucleus →	+0.057	+0.067	<.001	<.001	3	7
LIVER	Positive regulation of monoatomic ion transport →	-0.108	-0.386	<.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,348 associations by consensus.

Copper ion export by TMEM272 expression — LARGE_INTESTINE

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