TMEM270

Across TCGA cell cohorts, TMEM270 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMEM270-associated genes across cancer lineages are DEFB125 and OR2L5. Each is linked with TMEM270 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM270-to-partner and partner-to-TMEM270 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB125 grouped by TMEM270-low versus TMEM270-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM270→partner) and Y-score (partner→TMEM270) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFB125 →	+0.029	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.019	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

DEFB125 by TMEM270 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →