TMEM270

Across TCGA pan-cancer cohorts, TMEM270 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM270’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM270 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM270 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, KIRP, and KICH are the cancer types where TMEM270 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM270 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.799	<.001	11	view →
KIRP	All	II,III,IV	+1.248	<.001	9	view →
KICH	All	II,III,IV	−0.388	<.001	9	view →
HNSC	Male	II,III,IV	+0.722	<.001	8	view →
STAD	All	II,III,IV	+0.663	<.001	8	view →
THCA	All	All	+0.169	<.001	7	view →
BRCA	All	III,IV	+1.030	<.001	6	view →
BLCA	All	All	+0.770	.005	6	view →
LIHC	Male	All	+0.588	<.001	6	view →
LUSC	All	All	+0.791	<.001	4	view →
LUAD	All	All	+0.414	.007	3	view →
CHOL	All	All	+1.224	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM270–COAD

Open the COAD breakdown →