TMEM263

Across TCGA patient cohorts, TMEM263 mutation is significantly associated with the RNA expression of many other genes, with 964 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM263-associated genes across cancer lineages are PMM2P2, NDUFA5P9, and RPL19P1. Each is linked with TMEM263 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM263-to-partner and partner-to-TMEM263 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PMM2P2 grouped by TMEM263-low versus TMEM263-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM263→partner) and Y-score (partner→TMEM263) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PMM2P2 →	+0.141	+4.934	<.001	.002	3	2
CESC	NDUFA5P9 →	+0.088	+6.164	<.001	<.001	3	1
CESC	RPL19P1 →	+0.113	+4.669	<.001	.007	3	1
CESC	FABP7P1 →	+0.215	+4.601	<.001	.004	3	1
UCEC	H2BC14 →	+0.711	+4.010	<.001	<.001	3	1
UCEC	NOL12 →	+0.361	+3.202	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 964 associations by consensus.

PMM2P2 by TMEM263 expression — CESC

Explore this box plot interactively →