TMEM260

Across TCGA patient cohorts, TMEM260 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM260-associated genes across cancer lineages are S6_pS240_S244, C-Raf, and Cyclin-B1. Each is linked with TMEM260 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM260-to-partner and partner-to-TMEM260 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by TMEM260-low versus TMEM260-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM260→partner) and Y-score (partner→TMEM260) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.390	+2.115	.008	.017	3	2
UCEC	C-Raf →	+0.184	+2.736	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.726	+2.247	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.098	-2.432	.008	.018	3	1
UCEC	eIF4G →	+0.270	+2.999	.017	.035	3	1
UCEC	A-Raf_pS299 →	-0.119	-1.874	.006	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

S6_pS240_S244 by TMEM260 expression — UCEC

Explore this box plot interactively →