TMEM260

Across TCGA pan-cancer cohorts, TMEM260 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMEM260’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM260 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM260 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where TMEM260 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM260 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.754	<.001	11	view →
BLCA	All	III,IV	+0.786	<.001	10	view →
LIHC	Female	II,III,IV	+0.847	<.001	7	view →
KIRC	Male	II,III,IV	−0.464	<.001	7	view →
THCA	All	All	−0.260	<.001	7	view →
LUSC	Female	All	+0.762	<.001	6	view →
STAD	Male	All	+0.574	<.001	6	view →
CHOL	Male	All	+1.608	<.001	5	view →
UCEC	All	All	+0.489	.011	4	view →
COAD	Male	All	+0.501	<.001	3	view →
READ	All	All	+0.435	.022	3	view →
ESCA	All	All	+0.668	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMEM260–HNSC

Open the HNSC breakdown →