TMEM260

Across TCGA cell cohorts, TMEM260 mutation is significantly associated with the RNA expression of many other genes, with 424 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM260-associated genes across cancer lineages are OR11H6, MTNR1B, and PLA2G3. Each is linked with TMEM260 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM260-to-partner and partner-to-TMEM260 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by TMEM260-low versus TMEM260-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM260→partner) and Y-score (partner→TMEM260) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	2
OESOPHAGUS	MTNR1B →	+0.139	+4.906	<.001	.006	3	1
LARGE_INTESTINE	PLA2G3 →	+1.011	+3.347	.001	.005	3	1
LARGE_INTESTINE	CBY1 →	+0.574	+3.160	.003	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.075	+3.667	.002	<.001	3	1
LARGE_INTESTINE	TRIM37 →	+0.633	+3.169	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 424 associations by consensus.

OR11H6 by TMEM260 expression — CNS

Explore this box plot interactively →