Across TCGA cell cohorts, TMEM26 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM26-associated genes across cancer lineages are PDILT, FAM205C, and SPINK9. Each is linked with TMEM26 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM26-to-partner and partner-to-TMEM26 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM26→partner) and Y-score (partner→TMEM26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDILT →	+0.008	+4.437	<.001	.004	3	1
LARGE_INTESTINE	FAM205C →	+0.012	+4.437	<.001	.004	3	1
SKIN	SPINK9 →	+0.043	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	IL36B →	+0.021	+5.209	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

TMEM26 survival (RNA) · tumor vs normal (RNA) · all TMEM26 data types