TMEM26-AS1

Across TCGA pan-cancer cohorts, TMEM26-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated TMEM26-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM26-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM26-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, BRCA, and HNSC are the cancer types where TMEM26-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.870	0.716	<.001	107	view →
BRCA	OS	Median	III,IV	0.913	0.755	<.001	60	view →
HNSC	DFS	Quartile	III,IV	0.722	0.498	.001	49	view →
LGG	OS	Median	All	0.746	0.870	<.001	43	view →
GBM	OS	Quartile	All	0.238	0.649	<.001	33	view →
DLBC	DFS	Quartile	All	0.335	0.764	.003	33	view →
THCA	DFS	Quartile	II,III,IV	0.539	0.899	.004	29	view →
LIHC	OS	Median	II,III,IV	0.635	0.783	.014	24	view →
PAAD	OS	Quartile	All	0.188	0.561	.007	20	view →
STAD	DFS	Median	II,III,IV	0.580	0.457	.032	18	view →
KIRP	DFS	Tertile	All	0.919	0.801	.016	17	view →
READ	DFS	Quartile	All	0.870	0.449	.025	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

TMEM26-AS1–KIRC (DFS)

Open the KIRC breakdown →