TMEM259

Across TCGA patient cohorts, TMEM259 protein abundance is significantly associated with the RNA expression of many other genes, with 3,681 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM259-associated genes across cancer lineages are IGKV1D-8, CRYM, and TLE5. Each is linked with TMEM259 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM259-to-partner and partner-to-TMEM259 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM259 versus IGKV1D-8 in LUAD, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM259→partner) and Y-score (partner→TMEM259) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IGKV1D-8 →	-1.051	-0.299	<.001	.002	3	3
UCEC	CRYM →	-0.641	-0.377	.002	.004	3	2
OV	TLE5 →	+0.647	+0.463	<.001	<.001	3	2
OV	STK11 →	+0.487	+0.475	.002	.001	3	2
OV	C19orf25 →	+0.689	+0.548	<.001	<.001	3	2
OV	TMEM54 →	+1.108	+0.465	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,681 associations by consensus.

TMEM259 vs IGKV1D-8 — LUAD

Explore this scatter interactively →