TMEM259

Across TCGA cell cohorts, TMEM259 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,015 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM259-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Cytoplasm protein quality control by the ubiquitin-proteasome system, and Cytoplasm protein quality control. Each is linked with TMEM259 in more than 17 cancer types. Because this analysis shows association rather than direction, both TMEM259-to-partner and partner-to-TMEM259 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by TMEM259-low versus TMEM259-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM259→partner) and Y-score (partner→TMEM259) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.173	+1.153	<.001	<.001	3	18
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.191	+0.957	<.001	<.001	3	17
BONE	Cytoplasm protein quality control →	+0.167	+1.014	<.001	<.001	3	17
OESOPHAGUS	snoRNA guided rRNA pseudouridine synthesis →	-0.125	-1.137	<.001	.003	3	16
BONE	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.115	+1.165	<.001	<.001	3	16
BONE	Electron transport coupled proton transport →	+0.115	+1.165	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,015 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by TMEM259 expression — BONE

Explore this box plot interactively →