Across TCGA patient cohorts, TMEM256 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM256-associated genes across cancer lineages are MRPS17P5, SPATA48, and OR2AP1. Each is linked with TMEM256 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM256-to-partner and partner-to-TMEM256 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM256→partner) and Y-score (partner→TMEM256) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS17P5 →	+0.473	+6.049	<.001	.001	3	1
UCEC	SPATA48 →	+0.180	+4.606	.001	.004	3	1
UCEC	OR2AP1 →	+0.119	+4.852	<.001	.006	3	1
UCEC	OR5F2P →	+0.291	+4.398	<.001	.006	3	1
UCEC	OR4D8P →	+0.139	+4.694	<.001	.007	3	1
UCEC	TRAJ13 →	+1.324	+4.279	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

TMEM256 survival (RNA) · tumor vs normal (RNA) · all TMEM256 data types