Across TCGA patient cohorts, TMEM255B mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM255B-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and Notch1. Each is linked with TMEM255B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM255B-to-partner and partner-to-TMEM255B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM255B→partner) and Y-score (partner→TMEM255B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.294	-3.459	.019	.005	3	1
UCEC	mTOR_pS2448 →	-0.200	-2.321	.007	.035	3	1
UCEC	Notch1 →	+0.200	+2.817	.004	.036	3	1
UCEC	p62 Lck ligand →	+0.324	+2.321	.047	.035	3	1
UCEC	p70-S6K_pT389 →	-0.188	-2.321	.049	.035	3	1
UCEC	PCNA →	+0.231	+2.321	.033	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

TMEM255B survival (RNA) · tumor vs normal (RNA) · all TMEM255B data types