TMEM255A

Across TCGA cell cohorts, TMEM255A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,684 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM255A-associated GO terms across cancer lineages are Protein K48-linked ubiquitination, Negative regulation of response to biotic stimulus, and CD8-positive, alpha-beta T cell activation. Each is linked with TMEM255A in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM255A-to-partner and partner-to-TMEM255A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein K48-linked ubiquitination grouped by TMEM255A-low versus TMEM255A-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM255A→partner) and Y-score (partner→TMEM255A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Protein K48-linked ubiquitination →	+0.041	+1.078	.002	.004	3	12
BREAST	Negative regulation of response to biotic stimulus →	+0.072	+0.371	.004	.005	3	8
SOFT_TISSUE	CD8-positive, alpha-beta T cell activation →	+0.130	+1.146	<.001	.001	3	8
BREAST	Regulation of post-translational protein modification →	+0.069	+0.408	<.001	.001	3	8
BREAST	Regulation of protein modification by small protein conjugation or removal →	+0.065	+0.442	<.001	<.001	3	8
BREAST	Viral life cycle →	+0.058	+0.335	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,684 associations by consensus.

Protein K48-linked ubiquitination by TMEM255A expression — OVARY

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