TMEM255A

Across TCGA pan-cancer cohorts, TMEM255A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TMEM255A data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TMEM255A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM255A expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

UVM, BLCA, and LGG are the cancer types where TMEM255A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.399	0.752	<.001	100	view →
BLCA	OS	Median	All	0.546	0.692	.003	60	view →
LGG	OS	Median	All	0.724	0.896	<.001	54	view →
HNSC	DFS	Median	All	0.700	0.547	<.001	46	view →
LIHC	OS	Tertile	II,III,IV	0.405	0.749	<.001	41	view →
BRCA	OS	Median	All	0.980	0.944	<.001	37	view →
CHOL	DFS	Median	All	0.601	0.212	.003	34	view →
SKCM	DFS	Tertile	All	0.791	0.697	.002	34	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	24	view →
LUAD	OS	Median	II,III,IV	0.766	0.649	.008	12	view →
UCS	DFS	Median	III,IV	0.477	0.158	.030	8	view →
THCA	OS	Median	II,III,IV	0.963	1.000	.018	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TMEM255A–UVM (DFS)

Open the UVM breakdown →