TMEM252

Across TCGA patient cohorts, TMEM252 mutation is significantly associated with the RNA expression of many other genes, with 904 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM252-associated genes across cancer lineages are IFNNP1, CHEK2P1, and MIR1263. Each is linked with TMEM252 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM252-to-partner and partner-to-TMEM252 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNNP1 grouped by TMEM252-low versus TMEM252-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM252→partner) and Y-score (partner→TMEM252) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IFNNP1 →	+0.054	+5.468	<.001	.002	3	2
HNSC	CHEK2P1 →	+0.120	+4.736	.001	.007	3	2
COAD	MIR1263 →	+1.494	+7.741	<.001	.009	3	1
COAD	MIR1283-1 →	+0.726	+7.741	<.001	.009	3	1
COAD	MIR1179 →	+1.171	+7.741	<.001	.009	3	1
COAD	MTATP6P30 →	+0.147	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 904 associations by consensus.

IFNNP1 by TMEM252 expression — HNSC

Explore this box plot interactively →