TMEM25

Across TCGA patient cohorts, TMEM25 mutation is significantly associated with the RNA expression of many other genes, with 2,163 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM25-associated genes across cancer lineages are MIR3908, RNA5SP147, and RNA5SP175. Each is linked with TMEM25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM25-to-partner and partner-to-TMEM25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3908 grouped by TMEM25-low versus TMEM25-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM25→partner) and Y-score (partner→TMEM25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR3908 →	+0.270	+4.345	<.001	.002	3	2
LUSC	RNA5SP147 →	+0.492	+5.906	<.001	.001	3	2
CESC	RNA5SP175 →	+0.737	+4.269	<.001	.003	3	2
UCEC	RPL17-C18orf32 →	+0.038	+2.154	.003	<.001	3	2
UCEC	TSPY12P →	+0.011	+4.230	<.001	.004	3	2
UCEC	KIR3DL2 →	+0.214	+2.184	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,163 associations by consensus.

MIR3908 by TMEM25 expression — CESC

Explore this box plot interactively →