TMEM25

Across TCGA pan-cancer cohorts, TMEM25 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated TMEM25 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TMEM25 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM25 expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

KIRP, KIRC, and UVM are the cancer types where TMEM25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.968	0.851	<.001	114	view →
KIRC	DFS	Median	All	0.762	0.515	<.001	111	view →
UVM	OS	Median	All	0.786	0.424	<.001	110	view →
LUAD	DFS	Median	All	0.837	0.746	<.001	100	view →
SKCM	DFS	Median	II,III,IV	0.412	0.207	.002	44	view →
BRCA	DFS	Median	III,IV	0.865	0.728	.002	30	view →
LUSC	DFS	Tertile	III,IV	0.516	0.781	<.001	27	view →
KICH	OS	Median	All	0.774	0.969	.017	24	view →
ACC	DFS	Tertile	IV	0.118	0.549	.006	20	view →
ESCA	OS	Tertile	II,III,IV	0.735	0.391	.006	8	view →
PAAD	OS	Median	All	0.537	0.347	.020	8	view →
READ	OS	Quartile	IV	0.852	0.352	.024	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

TMEM25–KIRP (DFS)

Open the KIRP breakdown →