TMEM25

Across TCGA patient cohorts, TMEM25 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM25-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and eIF4E. Each is linked with TMEM25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM25-to-partner and partner-to-TMEM25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TMEM25-low versus TMEM25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM25→partner) and Y-score (partner→TMEM25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.754	+4.000	.001	<.001	3	2
UCEC	14-3-3_beta →	-0.117	-3.143	.006	.018	3	1
UCEC	eIF4E →	+0.223	+3.321	.012	.010	3	1
UCEC	A-Raf_pS299 →	-0.164	-3.459	.001	.005	3	1
UCEC	FOXO3a →	-0.088	-2.429	.041	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.154	-2.209	.031	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Cyclin-B1 by TMEM25 expression — UCEC

Explore this box plot interactively →