TMEM25

Across TCGA cell cohorts, TMEM25 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM25-associated genes across cancer lineages are MAGEB4, OR6Q1, and IL20. Each is linked with TMEM25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM25-to-partner and partner-to-TMEM25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by TMEM25-low versus TMEM25-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM25→partner) and Y-score (partner→TMEM25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	IL20 →	+0.218	+3.662	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MAGEB4 by TMEM25 expression — LARGE_INTESTINE

Explore this box plot interactively →