TMEM249

Across TCGA patient cohorts, TMEM249 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,112 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM249-associated proteins across cancer lineages are HSF1, HSPD1, and ATAD2. Each is linked with TMEM249 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM249-to-partner and partner-to-TMEM249 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM249 versus HSF1 in LUAD, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM249→partner) and Y-score (partner→TMEM249) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HSF1 →	+0.313	+0.233	<.001	<.001	3	4
BRCA	HSPD1 →	+0.306	+0.203	<.001	<.001	3	3
LUAD	ATAD2 →	+0.549	+0.158	<.001	<.001	3	3
LUAD	BUB1B →	+0.557	+0.163	.006	.003	3	3
BRCA	CDC20 →	+0.698	+0.247	<.001	<.001	3	3
BRCA	CENPF_S3079 →	+0.838	+0.295	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,112 associations by consensus.

TMEM249 vs HSF1 — LUAD

Explore this scatter interactively →