TMEM249

Across TCGA cell cohorts, TMEM249 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,677 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMEM249-associated GO terms across cancer lineages are Microtubule nucleation, Microtubule polymerization, and Regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with TMEM249 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM249-to-partner and partner-to-TMEM249 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule nucleation grouped by TMEM249-low versus TMEM249-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM249→partner) and Y-score (partner→TMEM249) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Microtubule nucleation →	+0.106	+0.556	<.001	.001	3	12
SOFT_TISSUE	Microtubule polymerization →	+0.117	+0.639	<.001	<.001	3	11
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.149	+0.518	<.001	<.001	3	11
SOFT_TISSUE	DNA topological change →	+0.145	+0.755	<.001	.003	3	10
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.165	+0.492	<.001	<.001	3	10
LUNG_SCLC	Spliceosomal complex assembly →	+0.102	+0.886	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,677 associations by consensus.

Microtubule nucleation by TMEM249 expression — URINARY_TRACT

Explore this box plot interactively →