TMEM249

Across TCGA cell cohorts, TMEM249 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM249-associated genes across cancer lineages are DRD3, GSG1L2, and CD300H. Each is linked with TMEM249 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM249-to-partner and partner-to-TMEM249 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DRD3 grouped by TMEM249-low versus TMEM249-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM249→partner) and Y-score (partner→TMEM249) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DRD3 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.026	+6.022	<.001	.001	3	1
LARGE_INTESTINE	CD300H →	+0.052	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DRD3 by TMEM249 expression — LARGE_INTESTINE

Explore this box plot interactively →