TMEM248

Across TCGA cell cohorts, TMEM248 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM248-associated genes across cancer lineages are OR3A1, C5orf52, and LYZL6. Each is linked with TMEM248 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM248-to-partner and partner-to-TMEM248 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR3A1 grouped by TMEM248-low versus TMEM248-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM248→partner) and Y-score (partner→TMEM248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR3A1 →	+0.976	+4.922	<.001	.009	3	1
BLOOD_Leukemia	C5orf52 →	+0.036	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	LYZL6 →	+0.039	+5.969	<.001	.001	3	1
LARGE_INTESTINE	MS4A4A →	+0.242	+3.678	<.001	.009	3	1
LARGE_INTESTINE	CLPSL1 →	+0.158	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR3A1 by TMEM248 expression — BLOOD_Leukemia

Explore this box plot interactively →