TMEM245

Across TCGA patient cohorts, TMEM245 protein abundance is significantly associated with the RNA expression of many other genes, with 13,230 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMEM245-associated genes across cancer lineages are PPP6C, UCK1, and ALAD. Each is linked with TMEM245 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM245-to-partner and partner-to-TMEM245 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM245 versus PPP6C in HNSC, with a Pearson correlation of 0.21.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM245→partner) and Y-score (partner→TMEM245) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPP6C →	+0.744	+0.340	.001	.005	3	5
BRCA	UCK1 →	+0.440	+0.686	<.001	<.001	3	5
LUAD	ALAD →	+0.500	+0.339	<.001	<.001	3	5
BRCA	COQ4 →	+0.553	+0.558	<.001	.002	3	5
UCEC	MANF →	-0.768	-0.589	<.001	<.001	3	5
UCEC	HSP90B1 →	-1.018	-0.747	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,230 associations by consensus.

TMEM245 vs PPP6C — HNSC

Explore this scatter interactively →