TMEM245

Across TCGA patient cohorts, TMEM245 mutation is significantly associated with the RNA expression of many other genes, with 1,624 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM245-associated genes across cancer lineages are SNORA59B, MTRNR2L2, and RN7SL478P. Each is linked with TMEM245 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM245-to-partner and partner-to-TMEM245 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA59B grouped by TMEM245-low versus TMEM245-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM245→partner) and Y-score (partner→TMEM245) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORA59B →	+0.156	+1.955	.005	.002	3	3
UCEC	MTRNR2L2 →	+0.433	+1.670	.002	.005	3	2
BLCA	RN7SL478P →	+0.255	+3.098	<.001	.007	3	2
COAD	RNU6-267P →	+0.933	+5.435	<.001	.005	3	2
KIRP	MTND4LP19 →	+0.232	+5.159	<.001	.007	3	2
BLCA	ART2BP →	+0.109	+4.985	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,624 associations by consensus.

SNORA59B by TMEM245 expression — UCEC

Explore this box plot interactively →