TMEM245

Across TCGA patient cohorts, TMEM245 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM245-associated genes across cancer lineages are EGFR_pY1068, p70-S6K_pT389, and 14-3-3_beta. Each is linked with TMEM245 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM245-to-partner and partner-to-TMEM245 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM245-low versus TMEM245-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM245→partner) and Y-score (partner→TMEM245) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.238	-2.502	.015	.002	3	2
UCEC	p70-S6K_pT389 →	-0.193	-3.321	.009	.009	3	2
UCEC	14-3-3_beta →	-0.086	-3.143	.028	.018	3	1
UCEC	eIF4E →	+0.191	+3.183	.020	.009	3	1
UCEC	eIF4G →	+0.272	+2.321	.025	.034	3	1
UCEC	GATA6 →	-0.166	-1.992	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by TMEM245 expression — UCEC

Explore this box plot interactively →