TMEM245

Across TCGA cell cohorts, TMEM245 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,416 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM245-associated GO terms across cancer lineages are Negative regulation of cilium assembly, Macroautophagy, and Positive regulation of viral process. Each is linked with TMEM245 in more than 14 cancer types. Because this analysis shows association rather than direction, both TMEM245-to-partner and partner-to-TMEM245 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cilium assembly grouped by TMEM245-low versus TMEM245-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM245→partner) and Y-score (partner→TMEM245) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of cilium assembly →	+0.095	+0.948	<.001	<.001	3	15
OESOPHAGUS	Macroautophagy →	+0.065	+1.170	<.001	<.001	3	15
LARGE_INTESTINE	Positive regulation of viral process →	+0.081	+1.000	<.001	<.001	3	14
BREAST	Nucleus organization →	+0.078	+0.805	<.001	<.001	3	14
BONE	Establishment of RNA localization →	+0.119	+0.882	.001	<.001	3	13
BREAST	Cell division →	+0.078	+0.745	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,416 associations by consensus.

Negative regulation of cilium assembly by TMEM245 expression — LUNG_NSCLC_LUSC

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