Across TCGA patient cohorts, TMEM242 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM242-associated genes across cancer lineages are eIF4E, ERK2, and Acetyl-a-Tubulin-Lys40. Each is linked with TMEM242 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM242-to-partner and partner-to-TMEM242 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM242→partner) and Y-score (partner→TMEM242) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.228	+3.700	.020	.001	3	1
UCEC	ERK2 →	+0.259	+3.169	.003	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.707	+2.584	.002	.011	3	1
UCEC	MEK1 →	+0.440	+3.321	.009	.010	3	1
UCEC	MSH2 →	-0.276	-2.584	.010	.011	3	1
UCEC	mTOR_pS2448 →	-0.191	-2.302	.006	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

TMEM242 survival (RNA) · tumor vs normal (RNA) · all TMEM242 data types