Across TCGA cell cohorts, TMEM240 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM240-associated genes across cancer lineages are TAS2R7, SEPTIN14, and NPY2R. Each is linked with TMEM240 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM240-to-partner and partner-to-TMEM240 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM240→partner) and Y-score (partner→TMEM240) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAS2R7 →	+0.014	+4.437	<.001	.004	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	NPY2R →	+0.005	+4.217	<.001	.001	3	1
LARGE_INTESTINE	BPIFA1 →	+0.235	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

TMEM240 survival (RNA) · tumor vs normal (RNA) · all TMEM240 data types