Across TCGA pan-cancer cohorts, TMEM240 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM240’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMEM240 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM240 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, UCEC, and BLCA are the cancer types where TMEM240 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM240 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.058	<.001	9	view →
UCEC	All	III,IV	−2.103	<.001	8	view →
BLCA	Male	III,IV	−1.648	<.001	8	view →
LIHC	Female	All	+0.307	<.001	7	view →
BRCA	All	II,III,IV	−0.419	<.001	6	view →
HNSC	All	II,III,IV	+0.260	.007	4	view →
KIRC	Male	All	−0.256	.003	4	view →
STAD	All	All	−0.616	.012	3	view →
READ	All	All	−1.055	.002	2	view →
CHOL	Male	All	+0.901	<.001	2	view →
PRAD	All	All	−0.566	<.001	2	view →
COAD	All	II,III,IV	−0.358	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

Exploration

Same gene, other analysis: TMEM240 RNA expression & survival · all TMEM240 data types