TMEM238

Across TCGA pan-cancer cohorts, TMEM238 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMEM238 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM238 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM238 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where TMEM238 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.834	0.475	<.001	43	view →
UCEC	DFS	Median	II,III,IV	0.432	0.871	.009	14	view →
LUAD	DFS	Median	II,III,IV	0.968	0.691	.016	5	view →
LSCC	DFS	Quartile	II,III,IV	0.837	1.000	.034	4	view →
PDAC	OS	Quartile	III,IV	1.000	0.409	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TMEM238–HNSC (DFS)

Open the HNSC breakdown →