TMEM238

Across TCGA pan-cancer cohorts, TMEM238 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM238’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM238 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM238 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, BLCA, and BRCA are the cancer types where TMEM238 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM238 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.572	<.001	10	view →
BLCA	Male	IV	+1.825	.015	6	view →
BRCA	All	III,IV	+1.351	<.001	6	view →
KICH	All	All	−0.649	.004	5	view →
COAD	All	All	+0.769	.007	4	view →
STAD	All	All	+1.538	<.001	3	view →
UCEC	All	All	+1.864	<.001	2	view →
CHOL	All	All	+1.258	.002	2	view →
PRAD	All	All	+0.721	<.001	2	view →
LIHC	All	All	+0.492	.006	2	view →
ESCA	All	All	+0.786	.038	1	view →
LUAD	Female	III,IV	+0.562	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM238–KIRC

Open the KIRC breakdown →