TMEM236

Across TCGA patient cohorts, TMEM236 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM236-associated genes across cancer lineages are ASNS, FoxM1, and Caspase-7-cleavedD198. Each is linked with TMEM236 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM236-to-partner and partner-to-TMEM236 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TMEM236-low versus TMEM236-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM236→partner) and Y-score (partner→TMEM236) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.513	+3.000	<.001	<.001	3	3
UCEC	FoxM1 →	+0.326	+2.736	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.575	+1.604	.008	.041	3	2
UCEC	CDK1 →	+0.143	+1.750	.010	.049	3	2
UCEC	EGFR_pY1068 →	-0.282	-2.736	.002	<.001	3	1
UCEC	eIF4E →	+0.181	+2.247	.019	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ASNS by TMEM236 expression — UCEC

Explore this box plot interactively →