TMEM236

Across TCGA cell cohorts, TMEM236 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,678 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM236-associated GO terms across cancer lineages are Regulation of protein localization to mitochondrion, Regulation of intracellular protein transport, and Positive regulation of protein K48-linked ubiquitination. Each is linked with TMEM236 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMEM236-to-partner and partner-to-TMEM236 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to mitochondrion grouped by TMEM236-low versus TMEM236-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM236→partner) and Y-score (partner→TMEM236) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of protein localization to mitochondrion →	+0.087	+0.093	<.001	.003	2	9
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular protein transport →	+0.081	+0.249	.001	<.001	3	8
LUNG_NSCLC_LUAD	Positive regulation of protein K48-linked ubiquitination →	+0.089	+0.141	.001	.007	3	8
BREAST	Negative regulation of amino acid biosynthetic process →	+0.297	+0.203	.001	.001	3	7
BREAST	Negative regulation of amino acid metabolic process →	+0.297	+0.203	.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular transport →	+0.056	+0.186	.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,678 associations by consensus.

Regulation of protein localization to mitochondrion by TMEM236 expression — SOFT_TISSUE

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