Across TCGA patient cohorts, TMEM235 mutation is significantly associated with the RNA expression of many other genes, with 543 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM235-associated genes across cancer lineages are RDM1, VWA1, and FCER1A. Each is linked with TMEM235 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM235-to-partner and partner-to-TMEM235 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM235→partner) and Y-score (partner→TMEM235) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RDM1 →	+0.618	+3.467	.001	.002	3	1
UCEC	VWA1 →	-1.221	-3.796	<.001	<.001	3	1
UCEC	FCER1A →	-0.856	-3.435	.003	.005	3	1
UCEC	ATP5F1EP2 →	+0.750	+3.338	.005	.005	3	1
UCEC	AEN →	+0.667	+3.475	<.001	.002	3	1
UCEC	CLN8 →	+0.534	+3.828	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 543 associations by consensus.

Exploration

TMEM235 survival (RNA) · tumor vs normal (RNA) · all TMEM235 data types