Across TCGA pan-cancer cohorts, TMEM235 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMEM235’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM235 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM235 is over-expressed in tumor, although a few such as THCA and LIHC show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where TMEM235 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM235 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.061	.001	8	view →
THCA	All	All	−0.020	<.001	3	view →
COAD	Female	II,III,IV	+0.027	.032	1	view →
LIHC	Male	All	−0.012	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TMEM235 RNA expression & survival · all TMEM235 data types