Across TCGA patient cohorts, TMEM235 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM235-associated genes across cancer lineages are IGFBP2, AMPK_pT172, and p62 Lck ligand. Each is linked with TMEM235 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM235-to-partner and partner-to-TMEM235 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM235→partner) and Y-score (partner→TMEM235) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.788	-3.169	.027	.020	3	1
UCEC	AMPK_pT172 →	+0.445	+3.183	.048	.010	3	1
UCEC	p62 Lck ligand →	+0.568	+3.169	.001	.020	1	1
UCEC	Di-Ras3 →	-0.178	-3.169	.029	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

TMEM235 survival (RNA) · tumor vs normal (RNA) · all TMEM235 data types