TMEM234

Across TCGA patient cohorts, TMEM234 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM234-associated genes across cancer lineages are RN7SKP181, MIR6853, and LINC02366. Each is linked with TMEM234 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM234-to-partner and partner-to-TMEM234 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by TMEM234-low versus TMEM234-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM234→partner) and Y-score (partner→TMEM234) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP181 →	+0.192	+3.133	<.001	.009	3	2
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1
BRCA	LINC02366 →	+0.057	+5.506	.008	.005	3	1
BRCA	MIR548AD →	+0.225	+7.471	<.001	.008	3	1
BRCA	TTTY7B →	+0.016	+7.471	<.001	.008	3	1
BRCA	CDY2A →	+0.019	+6.215	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

RN7SKP181 by TMEM234 expression — UCEC

Explore this box plot interactively →