TMEM234

Across TCGA pan-cancer cohorts, TMEM234 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM234’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM234 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM234 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where TMEM234 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM234 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.805	<.001	12	view →
COAD	Female	II,III,IV	+0.770	<.001	10	view →
LIHC	Female	II,III,IV	+1.080	<.001	9	view →
HNSC	Male	All	+0.580	<.001	9	view →
KICH	Female	II,III,IV	−1.602	<.001	8	view →
STAD	All	II,III,IV	+0.715	<.001	7	view →
BLCA	All	All	+0.617	.005	6	view →
UCEC	All	All	+0.464	.004	6	view →
LUAD	All	All	+0.307	<.001	6	view →
CHOL	Male	All	+2.321	<.001	5	view →
THCA	Female	All	+0.372	<.001	5	view →
ESCA	All	All	+0.667	.011	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM234–KIRC

Open the KIRC breakdown →