TMEM234

Across TCGA cell cohorts, TMEM234 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible TMEM234-associated genes across cancer lineages are WFDC13, SERPINA7, and PRR20C. Each is linked with TMEM234 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM234-to-partner and partner-to-TMEM234 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC13 grouped by TMEM234-low versus TMEM234-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM234→partner) and Y-score (partner→TMEM234) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WFDC13 →	+0.045	+4.922	<.001	.009	3	1
STOMACH	SERPINA7 →	+0.053	+4.129	<.001	.007	3	1
STOMACH	PRR20C →	+0.032	+4.129	<.001	.007	3	1
STOMACH	CCDC195 →	+0.252	+4.794	<.001	.001	3	1
STOMACH	ADAM7 →	+0.047	+4.285	<.001	.007	3	1
LARGE_INTESTINE	PABPC1L2B →	+0.022	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

WFDC13 by TMEM234 expression — BLOOD_Leukemia

Explore this box plot interactively →