TMEM229A

Across TCGA patient cohorts, TMEM229A mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM229A-associated genes across cancer lineages are Ku80, MEK1, and mTOR_pS2448. Each is linked with TMEM229A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM229A-to-partner and partner-to-TMEM229A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TMEM229A-low versus TMEM229A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM229A→partner) and Y-score (partner→TMEM229A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.272	+2.183	.027	.035	3	1
UCEC	MEK1 →	+0.523	+3.169	.006	.019	3	1
UCEC	mTOR_pS2448 →	-0.225	-2.980	.003	.036	2	2
UCEC	Notch1 →	+0.199	+3.009	.007	.019	3	1
UCEC	Tuberin →	+0.389	+3.009	.005	.019	3	1
UCEC	ATM →	-0.807	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Ku80 by TMEM229A expression — UCEC

Explore this box plot interactively →