TMEM229A

Across TCGA pan-cancer cohorts, TMEM229A RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TMEM229A data layer compared with 2 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher TMEM229A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM229A expression acts as an unfavorable survival marker, although some lineages such as ACC and PAAD show a favorable association.

KICH, UVM, and BLCA are the cancer types where TMEM229A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.043	0.971	<.001	96	view →
UVM	DFS	Median	II,III,IV	0.436	0.684	.004	66	view →
BLCA	OS	Tertile	II,III,IV	0.513	0.660	.002	62	view →
ACC	DFS	Median	All	0.829	0.392	<.001	47	view →
HNSC	OS	Tertile	All	0.436	0.639	.010	27	view →
UCEC	DFS	Tertile	All	0.777	0.859	.005	22	view →
LUSC	OS	Median	All	0.379	0.599	.003	22	view →
PAAD	OS	Tertile	All	0.572	0.428	.028	13	view →
THYM	DFS	Quartile	All	0.958	0.658	.009	12	view →
READ	DFS	Tertile	IV	0.112	0.811	.008	11	view →
STAD	OS	Median	III,IV	0.520	0.749	.012	9	view →
ESCA	DFS	Quartile	II,III,IV	0.116	1.000	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

TMEM229A–KICH (DFS)

Open the KICH breakdown →