Across TCGA patient cohorts, TMEM225 mutation is significantly associated with the RNA expression of many other genes, with 1,372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM225-associated genes across cancer lineages are LINC02438, PTTG1, and TC2N. Each is linked with TMEM225 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM225-to-partner and partner-to-TMEM225 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM225→partner) and Y-score (partner→TMEM225) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC02438 →	+0.599	+3.459	<.001	.005	3	3
SKCM	PTTG1 →	+0.703	+3.028	<.001	<.001	3	2
SKCM	TC2N →	-0.761	-1.919	.005	.005	3	2
UCEC	PHB →	+0.482	+3.492	.007	.002	3	2
UCEC	CHAF1A →	+0.842	+4.269	<.001	<.001	3	2
SKCM	MRPL58 →	+0.335	+1.957	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,372 associations by consensus.

Exploration

TMEM225 survival (RNA) · tumor vs normal (RNA) · all TMEM225 data types