Across TCGA pan-cancer cohorts, TMEM225 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TMEM225’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMEM225 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM225 is over-expressed in tumor, although a few such as THCA and PAAD show the opposite, repressed pattern.

THCA, PAAD, and PRAD are the cancer types where TMEM225 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM225 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.049	.006	6	view →
PAAD	Female	All	−0.090	.046	2	view →
PRAD	All	All	+0.009	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TMEM225 RNA expression & survival · all TMEM225 data types