Across TCGA patient cohorts, TMEM225 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM225-associated genes across cancer lineages are FoxM1, CDK1, and 14-3-3_beta. Each is linked with TMEM225 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM225-to-partner and partner-to-TMEM225 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM225→partner) and Y-score (partner→TMEM225) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.267	+2.321	.012	.006	3	2
SKCM	CDK1 →	+0.178	+2.115	.018	.018	3	2
UCEC	14-3-3_beta →	-0.091	-1.794	.029	.027	3	1
UCEC	FASN →	+0.338	+1.807	.038	.027	3	1
UCEC	p62 Lck ligand →	+0.284	+3.179	.034	.010	3	1
UCEC	PR →	-0.205	-2.999	.047	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

TMEM225 survival (RNA) · tumor vs normal (RNA) · all TMEM225 data types