Across TCGA cell cohorts, TMEM225 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMEM225-associated genes across cancer lineages are RETN, OR11H1, and PRR23B. Each is linked with TMEM225 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM225-to-partner and partner-to-TMEM225 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM225→partner) and Y-score (partner→TMEM225) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RETN →	+0.137	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR11H1 →	+0.030	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRR23B →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP12-1 →	+0.114	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	C7orf77 →	+0.025	+4.662	.008	.005	3	1
LUNG_NSCLC_LUAD	ARSF →	+0.038	+4.734	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TMEM225 survival (RNA) · tumor vs normal (RNA) · all TMEM225 data types